【Active Ingredients】Tilmicosin
【Description】This product is light yellow to reddish brown clear liquid.
【Pharmacological Effects】Pharmacodynamics - Tilmicosin is a semi-synthetic macrolide antibiotic for animals. It is strong against mycoplasma, and its antibacterial effect is similar to that of tylosin. The sensitive gram-positive bacteria include Staphylococcus aureus (including penicillin-resistant Staphylococcus aureus), Pneumococcus, Streptococcus, Bacillus anthracis, erysipelas suis, Listeria, Clostridium putrescens, Clostridium pneumophila and so on. Sensitive gram-negative bacteria include Haemophilus, meningococcus, Pasteurella, etc. It has stronger activity against Actinobacillus pleuropneumoniae, Pasteurella multocida and mycoplasma of livestock and poultry than tylosin. 95% of Pasteurella haemolytica strains are sensitive to this product.
Pharmacokinetics - It is absorbed quickly after subcutaneous injection, characterized by strong tissue penetration and large distribution volume (more than 2L/kg). The concentration in lung and milk is high, the half-life can reach 1~2 days, and the effective blood concentration can be maintained for a long time. After subcutaneous injection of 10mg/1kg body weight to cattle, the peak concentration of drug in blood can be reached within 1 hour, and the concentration in milk (more than 0.8μg/ml) can be maintained for 8~9 days. After one injection, the concentration of MICS in lung tissue was still higher than that of Pasteurella haemolytica (3.12 μ g/ml) within 3 days. On the third day after injection, the ratio of lung/serum tilmicosin concentration was about 60:1. After subcutaneous injection, theconcentration in milk was nearly 50 times higher than that in blood, and the elimination half-life was 33.8 hours.
【Drug Interactions】
(1)The combination of this product and epinephrine can increase the death of pigs.
(2)It has the same target as other macrolides and lincosamines, and should not be used at the same time.
(3)The combination with β-lactams shows antagonism.
【Indications】Macrolide antibiotics. Can be use for treating Actinobacillus pleuropneumoniae, Pasteurella and mycoplasma infection.
【Dosage and Administration】Subcutaneous injection: cattle, 0.033ml per 1kg body weight. Only one injection.
【Adverse Reactions】The toxic effect of this product on animals is mainly the cardiovascular system, which can cause tachycardia and decreased contractility. 50mg/kg subcutaneous injection can cause myocardial toxicity, and 150mg/kg can cause death.
【Precautions】
(1)Cows that produce milk for human consumption shall not be used during lactation.
(2)Meat calves are prohibited.
(3)Local reactions (edema, etc.) can occur after subcutaneous injection, and contact with eyes should be avoided.
(4)The cardiovascular state should be closely monitored when injecting this product.
【Withdrawal Period】35 days for cattle
【Specification】100ml:30g
【Package】100ml/ bottle
【Storage】Shadowed and well sealed.
【Validity Period】2 years
【Batch No.】
【Manufacture Date】
Net weight: 100g
